Conformational insight into PRC2 mutation from molecular dynamics simulations

被引：0
|
作者：
Abramyan, Tigran [1 ]
Suh, Junghyun
James, Lindsey [3 ]
Frye, Stephen
Kireev, Dmitri [2 ]
机构：
[1] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Chapel Hill, NC 27515 USA
[3] Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 255卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
377
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Therapeutically targeting PRC2 expression and dynamics in rhabdoid tumor
    Chasse, Maggie H.
    Boguslawski, Elissa A.
    Sorensen, Katie M.
    Wernette, Courtney E.
    Goosen, Susan M.
    Grohar, Patrick J.
    CANCER RESEARCH, 2018, 78 (19)
  • [2] Molecular Insight into Cu2+-Induced Conformational Transitions of Amyloid β-Protein from Fast Kinetic Analysis and Molecular Dynamics Simulations
    Xu, Shaoying
    Wang, Wenjuan
    Dong, Xiaoyan
    Sun, Yan
    ACS CHEMICAL NEUROSCIENCE, 2021, 12 (02): : 300 - 310
  • [3] PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function
    Liu, Xiuli
    Liu, Xin
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [4] Molecular Dynamics Simulations of Factor Xa: Insight into Conformational Transition of Its Binding Subsites
    Singh, Narender
    Briggs, James M.
    BIOPOLYMERS, 2008, 89 (12) : 1104 - 1113
  • [5] Conformational Changes of Glutamine 5′-Phosphoribosylpyrophosphate Amidotransferase for Two Substrates Analogue Binding: Insight from Conventional Molecular Dynamics and Accelerated Molecular Dynamics Simulations
    Li, Congcong
    Chen, Siao
    Huang, Tianci
    Zhang, Fangning
    Yuan, Jiawei
    Chang, Hao
    Li, Wannan
    Han, Weiwei
    FRONTIERS IN CHEMISTRY, 2021, 9
  • [6] MOLECULAR-DYNAMICS SIMULATIONS OF THE CONFORMATIONAL DYNAMICS OF TRYPTOPHAN
    GORDON, HL
    JARRELL, HC
    SZABO, AG
    WILLIS, KJ
    SOMORJAI, RL
    JOURNAL OF PHYSICAL CHEMISTRY, 1992, 96 (04): : 1915 - 1921
  • [7] Insight on mutation-induced resistance to anaplastic lymphoma kinase inhibitor ceritinib from molecular dynamics simulations
    He, Mu-Yang
    Li, Wei-Kang
    Meiler, Jens
    Zheng, Qing-Chuan
    Zhang, Hong-Xing
    BIOPOLYMERS, 2019, 110 (02)
  • [8] Insight the C-Site Pocket Conformational Changes Responsible for Sirtuin 2 Activity Using Molecular Dynamics Simulations
    Sakkiah, Sugunadevi
    Arooj, Mahreen
    Cao, Guang Ping
    Lee, Keun Woo
    PLOS ONE, 2013, 8 (03):
  • [9] Molecular Dynamics Simulations: Insight into Molecular Phenomena at Interfaces
    Razavi, Sepideh
    Koplik, Joel
    Kretzschmar, Ilona
    LANGMUIR, 2014, 30 (38) : 11272 - 11283
  • [10] Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
    Xueyin Wang
    Richard D Paucek
    Anne R Gooding
    Zachary Z Brown
    Eva J Ge
    Tom W Muir
    Thomas R Cech
    Nature Structural & Molecular Biology, 2017, 24 : 1028 - 1038
12345