Design and synthesis of dysidiolide analogs from vitamin D3:: novel class of Cdc25A inhibitors

被引：28
|
作者：
Shimazawa, R
Suzuki, T
Dodo, K
Shirai, R
机构：
[1] Nara Inst Sci & Technol, Res & Educ Ctr Mat Sci, Nara 6300101, Japan
[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 12期
关键词：
dysidiolide; Cdc25A; dual-specificity phosphatase; enzyme inhibitor; vitamin D-3;
D O I：
10.1016/j.bmcl.2004.03.100
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D-3. These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC50 = 0.44-0.89 muM). (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3291 / 3294
页数：4
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