Polyene macrolide antibiotics: Mechanisms of inactivation, ways of stabilization, and methods of disposal of unusable drugs (Review)

被引：8

作者：

Belakhov, V. V. ^{[1
]}

Garabadzhiu, A. V. ^{[2
]}

机构：

[1] Technion Israel Inst Technol, Schulich Fac Chem, IL-32000 Haifa, Israel

[2] Tech Univ, St Petersburg State Inst Technol, Mol Pharmacol Lab, St Petersburg 190013, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2015年 / 85卷 / 13期

关键词：

polyene macrolide antibiotics; mechanisms of inactivation; methods of stabilization; nanoderivatives; disposal of drugs; AMPHOTERICIN-B; PHYSICOCHEMICAL CHARACTERISTICS; ANTIFUNGAL ANTIBIOTICS; OPTIMIZING EFFICACY; CIRCULAR-DICHROISM; ANTIMYCOTIC DRUGS; SELF-ASSOCIATION; LEVORIN; NYSTATIN; NANOPARTICLES;

D O I：

10.1134/S1070363215130174

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Published data concerning various mechanisms of the inactivation of polyene macrolide antibiotics, ways of their stabilization, and search for new stable dosage forms prepared with the use of nanotechnology techniques were summarized. Environmentally acceptable ways of disposal of pharmaceutical waste, and in particular polyene macrolide antibiotics, were discussed.

引用

页码：2985 / 3001

页数：17

共 2 条

[1] Polyene macrolide antibiotics: Mechanisms of inactivation, ways of stabilization, and methods of disposal of unusable drugs (Review)
V. V. Belakhov
A. V. Garabadzhiu
Russian Journal of General Chemistry, 2015, 85 : 2985 - 3001
[2] Review of the Anti-Candida albicans Activity and Physical Properties of Soft Lining Materials Modified with Polyene Antibiotics, Azole Drugs, and Chlorohexidine Salts
Barszczewska-Rybarek, Izabela
Kula, Patrycja
Chladek, Grzegorz
MATERIALS, 2024, 17 (21)

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