ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF A FREE BOUNDARY PROBLEM MODELLING THE GROWTH OF TUMORS WITH STOKES EQUATIONS

被引:14
|
作者
Wu, Junde [1 ]
Cui, Shangbin [1 ]
机构
[1] Sun Yat Sen Univ, Dept Math, Guangzhou 510275, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Free boundary problem; tumor growth; Stokes equations; stationary solution; asymptotic stability; CARCINOMA IN-SITU; NONNECROTIC TUMORS; MATHEMATICAL-MODEL; WELL-POSEDNESS; BIFURCATION; STABILITY; BREAST; INHIBITORS;
D O I
10.3934/dcds.2009.24.625
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
We study a free boundary problem modelling the growth of non-necrotic tumors with fluid-like tissues. The fluid velocity satisfies Stokes equations with a source determined by the proliferation rate of tumor cells which depends on the concentration of nutrients, subject to a boundary condition with stress tensor effected by surface tension. It is easy to prove that this problem has a unique radially symmetric stationary solution. By using a functional approach, we prove that there exists a threshold value gamma(*) > 0 for the surface tension coefficient gamma, such that in the case gamma > gamma(*) this radially symmetric stationary solution is asymptotically stable under small non-radial perturbations, whereas in the opposite case it is unstable.
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页码:625 / 651
页数:27
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