Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing

被引:13
|
作者
Holmes, Anthony [1 ]
Brown, Robert [2 ]
Shakesheff, Kevin [3 ]
机构
[1] Natl Ctr Replacement Refinement & Reduct Anim Res, London W1B 1AL, England
[2] Univ Coll London, Royal Natl Orthopaed Hosp, UCL TREC, Inst Orthopaed, Stanmore HA7 4LP, Middx, England
[3] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England
基金
英国工程与自然科学研究理事会;
关键词
3Rs; alternative; animal model; in vitro; NC3Rs; regenerative medicine; replacement; safety testing; stem cells; tissue engineering; LYMPH-NODE ASSAY; IN-VITRO APPROACH; SKIN SENSITIZATION; INSULIN-SECRETION; AIRWAY WALL; BRONCHOALVEOLAR LAVAGE; BRONCHIAL EPITHELIUM; RESPIRATORY-TRACT; CONSUMER SAFETY; CELL LINE;
D O I
10.2217/RME.09.26
中图分类号
Q813 [细胞工程];
学科分类号
摘要
The focus for the rapid progress in the field of tissue engineering has been the clinical potential of the technology to repair, replace, maintain or enhance the function of a particular tissue or organ. However, tissue engineering has much wider applicability in basic research and safety testing, which is often not recognized owing to the clinical focus of tissue engineers. Using examples from a recent National Centre for the Replacement, Refinement and Reduction of Animals in Research/Biotechnology and Biological Sciences Research Council symposium, which brought together tissue engineers and scientists from other research communities, this review highlights the potential of tissue engineering to provide scientifically robust alternatives to animals to address basic research questions and improve drug and chemical development in the pharmaceutical and chemical industries.
引用
收藏
页码:579 / 592
页数:14
相关论文
共 50 条
  • [1] Applying informatics in tissue engineering
    Xu, J
    Zhou, XL
    Yang, DP
    Ge, HY
    Wang, Q
    Tu, K
    Guo, TF
    [J]. METHODS OF INFORMATION IN MEDICINE, 2005, 44 (01) : 38 - 43
  • [2] Advanced tissue engineering for in vitro drug safety testing
    Róisín M. Owens
    [J]. MRS Communications, 2023, 13 : 685 - 694
  • [3] Advanced tissue engineering for in vitro drug safety testing
    Owens, Roisin M.
    [J]. MRS COMMUNICATIONS, 2023, 13 (05) : 685 - 694
  • [4] Assuring consumer safety without animals Applications for tissue engineering
    Westmoreland, Carl
    Holmes, Anthony M.
    [J]. ORGANOGENESIS, 2009, 5 (02) : 67 - 72
  • [5] Alternatives for corneal endothelial tissue engineering
    Thuret, Gilles
    [J]. ACTA OPHTHALMOLOGICA, 2022, 100
  • [6] Inclusion of Basic Adipose Tissue Engineering Research in a Lipofilling Procedure
    Doornaert, Maarten A. J.
    Blondeel, Phillip N.
    Stillaert, Filip B.
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2011, 127 (03): : 80E - 82E
  • [7] Tissue engineering and tissue repair in immunocompetent animals: Tissue construction and repair
    Cao, Y.
    Liu, W.
    Zhou, G.
    Cui, L.
    [J]. HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE, 2007, 39 (03) : 156 - 160
  • [8] Trends in tissue engineering research
    Hacker, Michael C.
    Mikos, Antonios G.
    [J]. TISSUE ENGINEERING, 2006, 12 (08): : 2049 - 2057
  • [9] Tissue engineering as a subdivision of bioprocess engineering - Reparative tissue engineering as a subspecialty of tissue engineering
    Kang, KA
    [J]. REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS, 2002, 961 : 216 - 219
  • [10] Tissue Engineering and Regenerative Medicine in Basic Research: A Year in Review of 2014
    Huang, Jia
    Lin, Xunxun
    Shi, Yuan
    Liu, Wei
    [J]. TISSUE ENGINEERING PART B-REVIEWS, 2015, 21 (02) : 167 - 176