Humoral immune responses to adenovirus vectors in the brain

被引：28

作者：

Kajiwara, K

Byrnes, AP

Ohmoto, Y

Charlton, HM

Wood, MJA

Wood, KJ

机构：

[1] Yamaguchi Univ, Sch Med, Dept Neurosurg, Yamaguchi 7558505, Japan

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

[3] Univ Oxford, Dept Human Anat, Oxford OX1 3QX, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 103卷 / 01期

基金：

英国医学研究理事会;

关键词：

adenovirus vectors; gene transfer; immune response; antibody; brain; beta-galactosidase;

D O I：

10.1016/S0165-5728(99)00220-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to beta-galactosidase. the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：8 / 15

页数：8

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