Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)

被引：24
|
作者：
Harneti, Desi [1 ]
Supriadin, Asep [1 ]
Ulfah, Mariam [1 ]
Safari, Agus [1 ]
Supratman, Unang [1 ]
Awang, Khalijah [2 ]
Hayashi, Hideo [3 ]
机构：
[1] Padjadjaran State Univ, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, Indonesia
[2] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 59100, Malaysia
[3] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Sakai, Osaka 5998531, Japan
来源：
PHYTOCHEMISTRY LETTERS | 2014年 / 8卷
关键词：
Stigmastane steroid; 3,4-Epoxy-(22R25)-tetrahydrofuran-stigmast-5-en; Aglaia eximia; Meliaceae; Cytotoxic activity; STIGMASTANE DERIVATIVES; DAMMARANE TRITERPENES; VERNONIA-GUINEENSIS; STEROIDS; LEAVES;
D O I：
10.1016/j.phytol.2014.01.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The new stigmastane steroid, 3,4-epoxy-(22R, 25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2-3) and two known steroids (4-5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 11.42, 4.26, 29.10, 45.96, and 52.09 mg/mL, respectively. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：28 / 31
页数：4
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