Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

被引:24
|
作者
Valour, F. [1 ,2 ,3 ]
Tasse, J. [3 ]
Trouillet-Assant, S. [3 ]
Rasigade, J. -P. [1 ,3 ]
Lamy, B. [4 ]
Chanard, E. [5 ]
Verhoeven, P. [6 ]
Decousser, J. -W. [7 ]
Marchandin, H. [4 ]
Bes, M. [3 ,8 ,9 ]
Chidiac, C. [2 ,3 ]
Vandenesch, F. [3 ,8 ,9 ]
Ferry, T. [2 ,3 ]
Laurent, F. [1 ,3 ,8 ,9 ]
机构
[1] Grp Hosp Nord, Lab Bacteriol, F-69004 Lyon, France
[2] Hosp Civils Lyon, Dept Infect Dis, Lyon, France
[3] Univ Lyon 1, Int Ctr Res Infect Dis, INSERM U1111, F-69365 Lyon, France
[4] Montpellier Univ Hosp, Dept Bacteriol, Montpellier, France
[5] Novescia, Dept Bacteriol, Lyon, France
[6] St Etienne Univ Hosp, Dept Bacteriol, St Etienne, France
[7] Hop Henri Mondor, AP HP, Dept Bacteriol, Paris, France
[8] Grp Hosp Est, Dept Bacteriol, Lyon, France
[9] Hosp Civils Lyon, French Natl Reference Ctr Staphylococci, Lyon, France
关键词
Clonal complex398; bone and joint infection; methicillin-susceptible Staphylococcus aureus; molecular epidemiology; nasal carriage; virulence factors;
D O I
10.1111/1469-0691.12567
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The prevalence of clonal complex (CC)398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates.
引用
收藏
页码:O772 / O775
页数:4
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