PHARMACOKINETICS OF PROPHYLACTIC MICAFUNGIN IN VERY-LOW-BIRTH-WEIGHT INFANTS

被引：19

作者：

Kawada, Mayumi ^{[1
]}

Fukuoka, Noriyasu ^{[2
]}

Kondo, Masatoshi ^{[3
]}

Okazaki, Kaoru ^{[3
]}

Kusaka, Takashi ^{[1
]}

Kawada, Kou ^{[1
]}

Itoh, Susumu ^{[1
,2
]}

机构：

[1] Kagawa Univ, Dept Pediat, Miki, Kagawa 7610793, Japan

[2] Kagawa Univ Hosp, Dept Pharm, Kagawa, Japan

[3] Tokyo Metropolitan Hachioji Childrens Hosp, Dept Neonatol, Tokyo, Japan

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2009年 / 28卷 / 09期

关键词：

micafungin; prophylactic use; very-low-birth-weight infants; pharmacokinetics; effect and safety; LATE-ONSET SEPSIS; FLUCONAZOLE; INFECTION; SAFETY;

D O I：

10.1097/INF.0b013e3181a0cfd1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the use of micafungin as a prophylaxis in very-low-birth-weight infants. Micafungin was first administered to 25 very-low-birth-weight infants 12 to 24 hours after birth at a dose of 1 mg/kg/d. the apparent volume of distribution, the apparent elimination rate constant, the elimination half-life, and the total body clearance (mean +/- SD) were 0.76 +/- 0.28 L/kg, 0.12 +/- 0.041 1/h, 6.7 +/- 2.2 h, and 0.089 +/- 0.047 L/kg/h, respectively.

引用

页码：840 / 842

页数：3

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