Pin1: A molecular orchestrator in the heart

被引：14
|
作者：
Hariharan, Nirmala [1 ]
Sussman, Mark A. [1 ]
机构：
[1] San Diego State Univ, Inst Heart, Dept Biol, San Diego, CA 92182 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2014年 / 24卷 / 06期
基金：
美国国家卫生研究院;
关键词：
PROLYL-ISOMERASE PIN1; DEPENDENT PROLINE ISOMERIZATION; PHOSPHORYLATION; CANCER; OVEREXPRESSION; STABILITY; SEQUENCE; RAF; AKT;
D O I：
10.1016/j.tcm.2014.05.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：256 / 262
页数：7
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