Cytotoxic Triterpenoids from the Stems of Microtropis japonica

被引：32

作者：

Chen, I-Hsiao ^{[1
]}

Lu, Mei-Chin ^{[1
]}

Du, Ying-Chi ^{[1
]}

Yen, Ming-Hong ^{[1
]}

Wu, Chin-Chung ^{[1
]}

Chen, Yung-Husan ^{[1
]}

Hung, Chih-Sheng ^{[1
]}

Chen, Shu-Li ^{[1
]}

Chang, Fang-Rong ^{[1
,2
,3
]}

Wu, Yang-Chang ^{[1
,2
,3
]}

机构：

[1] Kaohsiung Med Univ, Sch Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Natl Sun Yat Sen Univ, Kaohsiung Med Univ, Joint Res Ctr, Kaohsiung 804, Taiwan

[3] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期

关键词：

DIHYDROAGAROFURANOID SESQUITERPENE; URSOLIC ACID; ANTICANCER ACTIVITY; INHIBITORS; CELLS; CONSTITUENTS; EXTRACTS; ACETYLATION; ANTIOXIDANT; FOKIENENSIS;

D O I：

10.1021/np800694b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.

引用

页码：1231 / 1236

页数：6

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