Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation

被引：19

作者：

Madsen, Daniel H. ^{[1
]}

Bugge, Thomas H. ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Proteases & Tissue Remodeling Sect, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期

关键词：

cathepsin; collagenase; collagen endocytosis; Endo180; interstitial collagen degradation; in vivo imaging; lysosome; M2-polarized macrophages; mannose receptor; matrix metalloproteinase; Mrc1; Mrc2; tumor invasion; urokinase plasminogen activator receptor-associated protein; CANCER; CARCINOMAS; GROWTH; CELLS;

D O I：

10.4161/onci.27127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently described an assay for imaging interstitial collagen degradation in vivo, which allows for the identification of cell types and molecules involved in collagen turnover in the course of pathological and physiological tissue remodeling. The assay revealed a dominant role of receptor-mediated intracellular collagen degradation by M2-polarized macrophages in extracellular matrix turnover.

引用

页数：3