Two different karyotypes with 1q abnormalities in a patient with Fanconi anemia

被引：0
|
作者：
Oliveira, NISS
Ribeiro, EMSF
Raimondi, SC
Bittencourt, MA
Pasquini, R
Cavalli, LJ
机构：
[1] Univ Fed Parana, Dept Genet, Lab Citogenet Humana, UFPR, BR-81531970 Curitiba, Parana, Brazil
[2] St Jude Childrens Res Hosp, Dept Pathol, Cytogenet Lab, Memphis, TN 38105 USA
[3] UFPR, Hosp Clin, Serv Transplante Medula Ossea, Curitiba, Parana, Brazil
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 11期
关键词：
fancom anemia; duplication; deletion; 1q;
D O I：
10.1016/S0145-2126(02)00038-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of Fanconi anemia in which cytogenetic analysis of bone marrow (BM) samples revealed two distinct karyotypes: 46,XY,dup(1)(q21q42), in the first sample and 46,XY,del(1)(q32) in the second, aspirated 7 months later after acute myeloid leukemia (AML) developed. We discuss the cytogenetic clonal fluctuation common in Fanconi anemia, with the Fanconi's anemia (FA) reports available in the literature. Interestingly, we have identified that del(1)(q32) has not been reported before in FA. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1047 / 1049
页数：3
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