Recent progress in metal-organic frameworks for precaution and diagnosis of Alzheimer's disease

Alzheimer's disease (AD) has become an issue of common concern. With the increasing numbers of people with dementia, the precaution and diagnosis of AD is more and more important. Many reports have pointed out that the AD is closely related to four metal ions within human body, including Zn2+, Fe3+, Al3+ and Cu2+. On the other hand, magnetic resonance imaging (MRI) plays a key role in the diagnosis of AD. Metal-organic frameworks (MOFs), as one of the well-known inorganic-organic hybrid material, have a promising potential in sensing of AD related ions, as well as MRI contrast agent. In this review, we summarized the recent progress in revealing pathogeny and diagnose of AD and discussed the potential of MOFs in this area. Specifically, MOFs as luminescent sensors for Zn2+, Fe3+, Al3+ and Cu2+ ions and MRI contrast agents are highlighted. (C) 2018 Elsevier Ltd. All rights reserved.