Mandibular bone is protected against microarchitectural alterations and bone marrow adipose conversion in ovariectomized rats

被引:20
|
作者
Coutel, Xavier [1 ]
Delattre, Jerome [1 ]
Marchandise, Pierre [1 ]
Falgayrac, Guillaume [1 ]
Behal, Helene [2 ]
Kerckhofs, Greet [3 ,4 ,5 ,6 ]
Penel, Guillaume [1 ]
Olejnik, Cecile [1 ]
机构
[1] Univ Littoral Cote dOpale, Univ Lille, CHU Lille, EA 4490 PMOI, F-59000 Lille, France
[2] Univ Lille, CHU Lille, EA 2694 Sante Publ Epidemiol & Qual Soins, Unite Methodol & Biostat, F-59000 Lille, France
[3] UCLouvain, Inst Mech Mat & Civil Engn, Biomech Lab, Louvain, Belgium
[4] UCLouvain, Inst Expt & Clin Res, Woluwe St Lambert, Belgium
[5] Katholieke Univ Leuven, Dept Mat Engn, Leuven, Belgium
[6] Katholieke Univ Leuven, Div Skeletal Tissue Engn, Prometheus, Leuven, Belgium
基金
比利时弗兰德研究基金会;
关键词
Rats; Mandible; Ovariectomy; Aging; Bone microarchitecture; Bone marrow adipose tissue; Micro-CT; ESTROGEN-DEFICIENCY; ALVEOLAR BONE; TRABECULAR MICROARCHITECTURE; DYNAMIC HISTOMORPHOMETRY; MICRO-CT; OSTEOPOROSIS; FAT; TISSUE; AGE; DIFFERENTIATION;
D O I
10.1016/j.bone.2019.06.031
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoporosis is a disease that leads to a loss of bone mass and to alterations in the bone microarchitecture that occur in a site-specific manner; however it remains controversial in the jaw. The involvement of bone marrow adipose tissue (BMAT) in the bone metabolism has been suggested in several physiopathological contexts, such as in aging and osteoporosis. To test whether the BMAT content is related to mandibular bone loss, this study aimed to investigate the potential correlations between the trabecular bone microarchitecture on one hand and BMAT content and its spatial distribution in relation to bone surface on the other hand during aging and ovariectomy (OVX) during a long-term follow-up in a mature rat model. No age-related microarchitectural or BMAT changes were observed in the mandible. The OVX-induced bone loss was three-fold lower in the mandible than in the tibia and was observed only in the alveolar bone (not in the condyle). We also report a delayed increase in the mandibular BMAT content that remained 4-6-fold lower compared to tibia. This low BMAT content in the mandible was located at a distance from the trabecular bone surface (only 5% in contact with the bone surface versus 87% in the tibia). These findings highlight a specific mandibular response to OVX, in particular fewer microarchitectural alterations compared to that in the tibia. For the latter, the trabecular bone thickness and surface were correlated with the BMAT content. Oral functions may have a protective effect on the mandibular BMAT conversion in an OVX context.
引用
收藏
页码:343 / 352
页数:10
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