Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

被引：90
|
作者：
Choi, Bryan D. [1 ,2 ]
Suryadevara, Carter M. [1 ]
Gedeon, Patrick C. [3 ]
Herndon, James E., II [4 ]
Sanchez-Perez, Luis [1 ]
Bigner, Darell D. [2 ,5 ]
Sampson, John H. [1 ,2 ,5 ]
机构：
[1] Duke Univ, Med Ctr, Dept Surg, Duke Brain Tumor Immunotherapy Program,Div Neuros, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[3] Duke Univ, Dept Biomed Engn, Durham, NC 27710 USA
[4] Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2014年 / 21卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Central nervous system neoplasms; Epidermal growth factor receptor; Glioblastoma; Immunotherapy; T-lymphocytes; GROWTH-FACTOR RECEPTOR; T-CELLS; ADVERSE EVENT; SURVIVAL; THERAPY;
D O I：
10.1016/j.jocn.2013.03.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：189 / 190
页数：2
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