Process systems engineering approaches for drug product manufacturing: from tablets to injectables

被引：3

作者：

Sugiyama, Hirokazu ^{[1
]}

Matsunami, Kensaku ^{[1
]}

Yabuta, Keisho ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem Syst Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

来源：

27TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT C | 2017年 / 40C卷

基金：

日本学术振兴会;

关键词：

pharmaceuticals; continuous manufacturing; decontamination; process synthesis; decision-making;

D O I：

10.1016/B978-0-444-63965-3.50466-9

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Drug product manufacturing is a critical step to bring active pharmaceutical ingredient to usable forms for patients, such as tablets or injectables. This presentation showcases two recent outcomes from our research: one is on tablet manufacturing where there is a choice between batch and continuous technologies: the other is on injectable manufacturing where sterile environment needs to be established. The common points that both cases presented in regard to PSE was the relevance of process synthesis that supports process-oriented decision-makings in drug product manufacturing.

引用

页码：2785 / 2790

页数：6

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