Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer

被引：11
|
作者：
Janelsins, Michelle C. [1 ,2 ]
Lei, Lianlian [3 ]
Netherby-Winslow, Colleen [1 ]
Kleckner, Amber S. [1 ,2 ]
Kerns, Sarah [2 ,4 ]
Gilmore, Nikesha [1 ,2 ]
Belcher, Elizabeth [1 ,2 ]
Thompson, Bryan D. [1 ]
Werner, Zachary A. [1 ]
Hopkins, Judith O. [5 ]
Long, Joan [6 ]
Cole, Sharon [7 ]
Culakova, Eva [1 ]
机构：
[1] Univ Rochester, Dept Surg, Support Care Canc, 265 Crittenden Blvd, Rochester, NY 14642 USA
[2] Wilmot Canc Inst, Rochester, NY 14642 USA
[3] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
[4] Univ Rochester, Dept Radiat Oncol, Rochester, NY 14624 USA
[5] Southeast Clin Oncol Res Consortium SCOR, 2150 Country Club Rd Suite 200, Winston Salem, NC 27104 USA
[6] Canc Res Consortium West Michigan NCORP CRCWM, 25 Michigan St NE,Suite 3100, Grand Rapids, MI 49503 USA
[7] Dayton Clin Oncol Program, 3123 Res Blvd,Suite 150, Dayton, OH 45420 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 362卷
基金：
美国国家卫生研究院;
关键词：
Cognition; Cytokines  cancer; Chemotherapy; Cancer-related cognitive decline (CRCD); IMPAIRMENT; CHEMOTHERAPY; MEMORY; BRAIN; INTERLEUKIN-6; PERFORMANCE; MCP-1; MANAGEMENT; CONSTRUCT; VALIDITY;
D O I：
10.1016/j.jneuroim.2021.577769
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cancer-related cognitive decline (CRCD) is a clinically important problem and negatively affects daily functioning and quality of life. We conducted a pilot longitudinal study from pre-to post-chemotherapy in patients with breast cancer to assess changes in inflammation and cognition over time, as well as the impact of baseline cytokine level on post-chemotherapy cognitive scores. We found that concentrations of IL-6, MCP-1, sTNFRI, and sTNFRII significantly increased in patients, while IL-1 beta significantly decreased (p < 0.05). After controlling for covariates, increases in IL-6 and MCP-1 were associated with worse executive function and verbal fluency in patients from pre-to post-chemotherapy (p < 0.05). Higher baseline IL-6 was associated with better performance on executive function and verbal fluency post chemotherapy (p < 0.05). Overall, these results suggest that chemotherapy-associated increases in cytokines/receptors is associated with worse cognitive function. Larger studies are needed to confirm these findings.
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页数：8
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