SYNTHESIS, CRYSTAL STRUCTURE, AND BIOLOGICAL ACTIVITY OF SOME NOVEL SULFOXIDE COMPOUNDS CONTAINING 1,2,3-THIADIAZOLE MOIETY

被引：5

作者：

Min, Li-Jing ^{[1
]}

Yang, Ming-Yan ^{[2
]}

Mu, Jin-Xia ^{[4
]}

Sun, Zhao-Hui ^{[2
]}

Tan, Cheng-Xia ^{[2
]}

Weng, Jian-Quan ^{[2
]}

Liu, Xing-Hai ^{[2
]}

Zhang, Yong-Gang ^{[3
]}

机构：

[1] Huzhou Univ, Coll Life Sci, Huzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China

[3] Shandong Acad Sci, Inst Biol, Jinan, Peoples R China

[4] China Jiliang Univ, Coll Qual & Safety Engn, Hangzhou 310018, Zhejiang, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2015年 / 190卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Crystal structure; synthesis; 1; 2; 3-thiadiazole; sulfoxide; herbicidal activity; MICROWAVE ASSISTANT SYNTHESIS; ONE-POT SYNTHESIS; ANTIFUNGAL ACTIVITY; 1,2,4-TRIAZOLE DERIVATIVES; INHIBITORS; 3D-QSAR; DESIGN;

D O I：

10.1080/10426507.2015.1031755

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some new sulfoxide compounds containing 1,2,3-thiadiazole moiety were synthesized from diethyl carbonate and hydrazine hydrate by multi-step reactions. Their structures were confirmed by NMR, MS, and elemental analysis. One of the title compounds, 5-(4-cyclopropyl-5-((3-fluorobenzyl)sulfinyl)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole (C15H14FN5OS2), was structurally determined by a single crystal X-ray diffraction study. The biological activity of the title compound was determined, and the results showed that it displays moderate biological activities.

引用

页码：1884 / 1892

页数：9

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