Ganoboninketals A-C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat.

被引：45

作者：

Ma, Ke ^{[1
,2
]}

Ren, Jinwei ^{[1
]}

Han, Junjie ^{[1
]}

Bao, Li ^{[1
]}

Li, Li ^{[3
,4
]}

Yao, Yijian ^{[1
]}

Sun, Chen ^{[5
]}

Zhou, Bing ^{[5
]}

Liu, Hongwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

[5] Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ELECTRONIC CIRCULAR-DICHROISM; NORTRITERPENOID GLYCOSIDES; BULBS; ANTIMALARIAL;

D O I：

10.1021/np5002863

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new nortriterpenes, ganoboninketals A-C (1-3), featuring rearranged 3,4-seco-27-norlanostane skeletons and highly complex polycyclic systems were isolated from the medicinal mushroom Ganoderma boninense. The structures of the new metabolites were established by spectroscopic methods. The absolute configurations in 1-3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-3 showed antiplasmodial activity against Plasmodium falciparum with IC50 values of 4.0, 7.9, and 1.7 mu M, respectively. Compounds 1 and 3 also displayed weak cytotoxicity against A549 cell line with IC50 values of 47.6 and 35.8 mu M, respectively. Compound 2 showed weak cytotoxicity toward HeLa cell line with an IC50 value of 65.5 mu M. Compounds 1-3 also presented NO inhibitory activity in the LPS-induced macrophages with IC50 values of 98.3, 24.3, and 60.9 mu M, respectively.

引用

页码：1847 / 1852

页数：6

共 2 条

[1] Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXRβ
Ma, Ke
Li, Li
Bao, Li
He, Luwei
Sun, Chen
Zhou, Bing
Si, Shuyi
Liu, Hongwei
TETRAHEDRON, 2015, 71 (12) : 1808 - 1814
[2] Isolation of 3,4-seco-27-norlanostane triterpenoids from cultivated fruiting bodies of Ganoderma orbiforme
Li, Wei
Chinthanom, Panida
Rachtawee, Pranee
Intereya, Kamoiphan
Peng, Tao
Liu, Ji-Kai
Isaka, Masahiko
PHYTOCHEMISTRY LETTERS, 2018, 28 : 104 - 109

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