Domino N-H/C-H bond activation: Palladium-catalyzed synthesis of annulated heterocycles using dichloro(hetero)arenes

被引：278
|
作者：
Ackermann, Lutz [1 ]
Althammer, Andreas [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 10期
关键词：
C-C coupling; C-H activation; domino reactions; heterocycles; palladium;
D O I：
10.1002/anie.200603833
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) One after the other: A novel palladium-catalyzed domino reaction consisting of an amination and a direct C-H bond arylation allows for a general synthesis of annulated heterocycles starting from readily available 1,2-dichloroarenes and primary as well as secondary anilines (see scheme; Cy = cyclohexyl). This is high-lighted by an efficient synthesis of the natural product murrayafoline A. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1627 / 1629
页数：3
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