Augmentation of restless legs syndrome with long-term tramadol treatment

被引:59
|
作者
Vetrugno, Roberto
La Morgia, Chiara
D'Angelo, Roberto
Loi, Daniela
Provini, Federica
Plazzi, Giuseppe
Montagna, Pasquale
机构
[1] Univ Bologna, Dipartimento Sci Neurol, I-40123 Bologna, Italy
[2] Univ Cagliari, Dept Neurol, Cagliari, Italy
关键词
restless legs syndrome; augmentation; opioids; tramadol; polysomnography;
D O I
10.1002/mds.21342
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Restless legs syndrome (RLS) augmentation, defined as a kind of suppression of the circadian rhythm of the disease in which sensory and motor symptoms appear earlier during the day (and over previously unaffected body parts), with a progressive phase advance until, backwards, the symptoms may cover the entire day, has been described only after treatment with dopaminergic drugs. We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long-term treatment with tramadol, an opioid agonist with selectivity for mu-receptor and added norepinephrine and serotonin reuptake inhibition properties. Polysomnographic measures showed an improvement of RLS and a disappearance of diurnal sensory and motor RLS symptoms after tramadol was stopped. Our case confirms a recent retrospective report of augmentation of RLS after treatment with tramadol, and begs the question whether augmentation is truly restricted to dopaminergic drugs. (C) 2007 Movement Disorder Society.
引用
收藏
页码:424 / 427
页数:4
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