Glaucoma with Descemet's membrane detachment in five horses

被引:4
|
作者
Henriksen, Michala de Linde [1 ]
La Croix, Noelle [2 ]
Wilkie, David A. [3 ]
Lassaline-Utter, Mary [4 ]
Brantman, Karen R. [5 ]
Beamer, Gillian L. [6 ]
Teixeira, Leandro B. C. [7 ]
Dubielzig, Richard R. [7 ]
机构
[1] Univ Minnesota, Comparat Ophthalmol Serv, Dept Vet Clin Sci, Coll Vet Med, 1352 Boyd Ave, St Paul, MN 55108 USA
[2] Vet Med Ctr Long Isl, 75 Sunrise Highway, West Islip, NY 11795 USA
[3] Ohio State Univ, Comparat Ophthalmol, Dept Vet Clin Sci, 1900 Coffey Rd, Columbus, OH 43210 USA
[4] Univ Calif Davis, Dept Radiol & Surg Sci, Davis, CA 95616 USA
[5] Northwest Anim Eye Specialists, 13020 NE 85th St, Kirkland, WA 98033 USA
[6] Tufts Univ, Cummings Sch Vet Med, Dept Infect Dis & Global Hlth, 200 Westboro Rd, North Grafton, MA 01536 USA
[7] Univ Wisconsin, Comparat Ocular Pathol Lab Wisconsin, 2015 Linden Dr 3308, Madison, WI 53706 USA
关键词
corneal edema; Descemet's membrane detachment; equine; glaucoma; ocular hypertension; ophthalmology;
D O I
10.1111/vop.12388
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
PurposeTo describe the clinical and histopathologic features of glaucoma associated with Descemet's membrane (DM) detachment in five horses without prior history of intraocular surgery. Animals studiedThree Appaloosa horses and two Thoroughbreds were included in this study. The affected horses ranged in age from 16 to 27years and presented with severe diffuse corneal edema. ProcedureFive eyes were enucleated due to intraocular hypertension and/or chronic corneal ulceration. The enucleated globes were evaluated by the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW). Each globe was routinely processed for histopathology and analyzed by light microscopy. A histologic diagnosis of glaucoma was reached by demonstrating a loss of optic nerve axonal tissue by measuring neurofilament-immunopositive axons with automated image analysis software. ResultsAll five horses presented with unilateral severe diffuse corneal edema that had developed between 2 and 16weeks prior to enucleation. Intraocular pressures for the affected eyes were between 9 and 87mmHg prior to enucleation. Descemet's membrane detachment was identified histopathologically in all five globes (5/5, 100%). All five eyes had an avascular spindle cell proliferation filling the space between the displaced peripheral DM and the corneal stroma. Neurofilament immunostaining revealed axonal loss consistent with glaucoma. ConclusionEquine glaucoma may be associated with Descemet's membrane detachment. This detachment and glaucoma is a possible differential diagnosis for severe equine corneal edema. In this case series, an eye with a DM detachment had a poor prognosis for retention.
引用
收藏
页码:273 / 279
页数:7
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