Detecting occult coronary artery disease followed by early coronary artery bypass surgery in patients with diabetic retinopathy: Report from a diabetic retinocoronary clinic

被引:7
|
作者
Ohno, Takayuki [1 ]
Kinoshita, Osamu
Fujita, Hideo [2 ]
Kato, Satoshi [3 ]
Hirose, Akira [3 ]
Sigeeda, Takashi [3 ]
Otomo, Kazuyoshi [3 ]
Ando, Jiro [2 ]
Kadowaki, Takashi [4 ]
Araie, Makoto [3 ]
Nagai, Ryozo [2 ]
Takamoto, Shinichi
机构
[1] Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Dept Cardiol, Tokyo 1138655, Japan
[3] Univ Tokyo, Dept Ophthalmol, Tokyo 1138655, Japan
[4] Univ Tokyo, Dept Endocrinol & Metab, Tokyo 1138655, Japan
来源
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 2010年 / 139卷 / 01期
关键词
SILENT-MYOCARDIAL-ISCHEMIA; HEART-DISEASE; GRAFT-SURGERY; MORTALITY; IMPACT; RISK; ATHEROSCLEROSIS; ASSOCIATION; SURVIVAL; MELLITUS;
D O I
10.1016/j.jtcvs.2009.04.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: We hypothesized that a large number of patients with diabetic retinopathy who could benefit greatly from early coronary artery bypass grafting would not be identified. Methods: Patients with diabetic retinopathy receiving ophthalmologic care as outpatients in our hospital in whom coronary artery disease was not previously suspected were referred randomly to the diabetic retinocoronary clinic and were asked to participate in diagnostic tests, including an exercise treadmill test and exercise thallium scintigraphy or coronary computed tomography. Patients who had type 1 diabetes mellitus, required hemodialysis, or both were excluded from this study. A definitive diagnosis of coronary artery disease was confirmed by means of coronary angiography. Results: Of 214 patients with diabetic retinopathy, 55 (25.7%) were confirmed as having significant stenotic coronary artery disease. Patients with angiographically confirmed coronary disease were older than those with negative results on diagnostic tests (62.2 +/- 9.8 vs 57.9 +/- 10.3 years, P = .01). Fifteen had 1-vessel disease, 17 had 2-vessel disease, 14 had 3-vessel disease, 1 had left main trunk plus 1-vessel disease, 2 had left main trunk plus 2-vessel disease, and 5 had left main trunk plus 3-vessel disease. Eight patients had left main trunk disease, and 18 patients with non-left main trunk disease had proximal left anterior descending coronary artery (LAD) disease. Forty-two patients showed indications of coronary revascularization (coronary artery bypass grafting in 17 and percutaneous coronary intervention in 25). During the entire follow-up (287.6 +/- 183.2 days) of 39 patients undergoing coronary revascularization, all were alive without myocardial infarction, but 8 experienced vitreous hemorrhage. Conclusions: Approximately 25% of patients with diabetic retinopathy receiving ophthalmologic care as outpatients have a significant stenotic coronary artery disease. Of the total diabetic population, a large number of patients with diabetic retinopathy who show strong indications for early coronary artery bypass grafting might well go unrecognized. (J Thorac Cardiovasc Surg 2010; 139: 92-7)
引用
收藏
页码:92 / 97
页数:6
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