Significance of CD66c expression in childhood acute lymphoblastic leukemia

被引：21
|
作者：
Kiyokawa, Nobutaka [1 ]
Iijima, Kazutoshi [1 ]
Tomita, Osamu [1 ]
Miharu, Masashi [1 ,2 ]
Hasegawa, Daisuke [1 ,3 ]
Kobayashi, Kenichiro [1 ]
Okita, Hajime [1 ]
Kajiwara, Michiko [4 ]
Shimada, Hiroyuki [2 ]
Inukai, Takeshi
Makimoto, Atsushi [5 ,6 ]
Nanmoku, Toru
Koh, Katsuyoshi
Manabe, Atsushi
Kikuchi, Akira
Fujimoto, Junichiro
Hayashi, Yasuhicie
Ohara, Akira
机构：
[1] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Setagaya Ku, Tokyo 1578535, Japan
[2] Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan
[3] St Lukes Int Hosp, Dept Pediat, Chuo Ku, Tokyo, Japan
[4] Tokyo Med & Dent Univ, Hosp Med, Dept Transfus Med, Tokyo, Japan
[5] Univ Yamanashi, Dept Pediat, Sch Med, Chuo Ku, Yamanashi, Japan
[6] Natl Canc Ctr, Div Pediat Oncol, Chuo Ku, Tokyo, Japan
来源：
LEUKEMIA RESEARCH | 2014年 / 38卷 / 01期
关键词：
CD66c; Acute lymphoblastic leukemia; CRLF2; Flow cytometry; Genetic abnormality; CROSS-REACTING ANTIGEN; MONOCLONAL-ANTIBODY; KOR-SA3544; ANTIGEN; POOR-PROGNOSIS; CRLF2; CHILDREN; GENE; REARRANGEMENT; HYPODIPLOIDY; DISTINCT;
D O I：
10.1016/j.leukres.2013.10.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Upon analyze in 695 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD36c expression. In addition to the confirmation of wrong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chiineric gene-negative foss ell as hypediploid cases (314 whereas Sic never expressed in ETVA-RUNX1 MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases, Although the expression CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BC P-ALL indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：42 / 48
页数：7
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