Elevated plasma DNA in patients with NASH and reduced liver injury in mice with absence of TLR9 on Kupffer cells

被引：0

作者：

Garcia-Martinez, Irma ^{[1
]}

Ouyang, Xinshou ^{[1
]}

Santoro, Nicola ^{[2
]}

Shlomchik, Mark J. ^{[3
]}

Mehal, Wajahat Z. ^{[1
]}

机构：

[1] Yale Univ, Sect Digest Dis, Dept Internal Med, New Haven, CT USA

[2] Yale Univ, Dept Pediat, Sect Endocrinol, New Haven, CT 06520 USA

[3] Univ Pittsburg, Dept Immunobiol, Pittsburgh, PA USA

来源：

HEPATOLOGY | 2014年 / 60卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

654

引用

页码：517A / 517A

页数：1

共 18 条

[1] Humans and Mice With NASH Have Increased Plasma Levels of TLR9 Ligand, and a TLR7/9 Bifunctional Antagonist Reduces NASH in Mice
Garcia-Martinez, Irma
Santoro, Nicola
Chen, Yonglin
Ouyang, Xinshou
Caprio, Sonia
Coffman, Robert L.
Candia, Albert
Mehal, Wajahat Z.
GASTROENTEROLOGY, 2015, 148 (04) : S974 - S974
[2] A distinct role for the TLR9 pathway in immune activation and tolerance during acute liver injury in mice
Nakamoto, Nobuhiro
Ebinuma, Hirotoshi
Taniki, Nobuhito
Wakayama, Yuko
Chu, Po-sung
Yamaguchi, Akihiro
Amiya, Takeru
Saito, Hidetsugu
Kanai, Takanori
HEPATOLOGY, 2014, 60 : 519A - 519A
[3] Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
Spies, B
Hochrein, H
Vabulas, M
Huster, K
Busch, DH
Schmitz, F
Heit, A
Wagner, H
JOURNAL OF IMMUNOLOGY, 2003, 171 (11): : 5908 - 5912
[4] Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9
Xie, Qing
Shen, Huai-Cheng
Jia, Ni-Na
Wang, Hui
Lin, Lan-Yi
An, Bao-Yan
Gui, Hong-Lian
Guo, Si-Min
Cai, Wei
Yu, Hong
Guo, Qing
Bao, Shisan
MICROBES AND INFECTION, 2009, 11 (04) : 515 - 523
[5] Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression
Tu, Chuan-tao
Han, Bing
Yao, Qun-yan
Zhang, Yi-an
Liu, Hong-chun
Zhang, Shun-cai
INTERNATIONAL IMMUNOPHARMACOLOGY, 2012, 12 (01) : 151 - 157
[6] Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury
Hotz, Meghan J.
Qing, Danielle
Shashaty, Michael G. S.
Zhang, Peggy
Faust, Hilary
Sondheimer, Neal
Rivella, Stefano
Worthen, G. Scott
Mangalmurti, Nilam S.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197 (04) : 470 - 480
[7] Limited expression of TLR9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease
Soledad Alegre, Nadia
Claudia Garcia, Cecilia
Ariel Billordo, Luis
Ameigeiras, Beatriz
Poncino, Daniel
Benavides, Javier
Colombato, Luis
Claudia Chernavsky, Alejandra
CLINICAL AND MOLECULAR HEPATOLOGY, 2020, 26 (02) : 216 - 226
[8] A unique subset of CD11c-positive dendritic cells mediate immunological tolerance via TLR9 in Concanavalin A-induced liver injury in mice
Nakamoto, Nobuhiro
Ebinuma, Hirotoshi
Kanai, Takanori
Wakayama, Yuko
Taniki, Nobuhito
Murata, Hiroko
Mikami, Yohei
Chu, Po-sung
Sugiyama, Kazuo
Saito, Hidetsugu
Hibi, Toshifumi
HEPATOLOGY, 2013, 58 : 447A - 447A
[9] CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells
Hou, Xin
Hao, Xiaolei
Zheng, Meijuan
Xu, Congfei
Wang, Jun
Zhou, Rongbin
Tian, Zhigang
CELLULAR & MOLECULAR IMMUNOLOGY, 2017, 14 (08) : 675 - 684
[10] CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells
Xin Hou
Xiaolei Hao
Meijuan Zheng
Congfei Xu
Jun Wang
Rongbin Zhou
Zhigang Tian
Cellular & Molecular Immunology, 2017, 14 : 675 - 684

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