The rapid development of industrial automation and computer technology has brought favorable conditions for the process to carry out computer integrated process system. This article mainly analyzes the developmental process of the computer integrated process system, discusses the technical framework of process management system, and the real-time database and system security in key technology. Using.NET technology, and based on the real-time database and relational database, the process management system is developed, which includes process scheduling, quality supervision, measurement, technique and procedure management and report system. The process management system is successfully applied in coal chemical industry. The results of application show that the process management system can bring about more economic benefits for enterprise.