Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient

被引:6
|
作者
Wong, Tak-Wah [1 ,2 ]
Hughes, Michael [3 ]
Wang, Szu-Han [1 ]
机构
[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Dermatol, Tainan, Taiwan
[2] Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan, Taiwan
[3] Natl Cheng Kung Univ, Coll Med, Grad Inst Clin Med, Tainan, Taiwan
关键词
Basal cell carcinoma; Hair follicle; Regeneration; Secondary intention healing; SKIN; CELLS;
D O I
10.1016/j.jtv.2018.01.001
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Hair regeneration in elderly scalp wound has never been observed. We reported an 80-year-old patient with a large wound on the scalp after excision of a basal cell carcinoma healed by secondary intention wound healing. The patient's wound healed very well aesthetically. Interestingly, on approximate post wound day 180, a hair was observed to be growing towards the surface and eventually erupted in the center of the wound. The hair remained black at 42-month follow-up. This case demonstrated that neogenesis of hair is possible even in geriatric patient. To the best of our knowledge, this is the first report of hair regrow in human skin after wound healing. (C) 2018 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
引用
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页码:114 / 116
页数:3
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