Unique and convenient use of raney nickel for the reduction of aryl bromides, benzyl alcohols, benzyl ethers and benzylamines in an acidic medium

被引：8

作者：

Okimoto, M ^{[1
]}

Takahashi, Y ^{[1
]}

Nagata, Y ^{[1
]}

Satoh, M ^{[1
]}

Sueda, S ^{[1
]}

Yamashina, T ^{[1
]}

机构：

[1] Kitami Inst Technol, Dept Appl & Environm Chem, Kitami, Hokkaido 0908507, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2004年 / 77卷 / 07期

关键词：

D O I：

10.1246/bcsj.77.1405

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and convenient method for laboratory-scale reduction using Raney nickel is described. The reaction was achieved by the inclusion of sulfuric acid to a mixture of a substrate and Raney nickel. Using this method, several aryl bromides, benzyl alcohols, benzyl ethers, and benzylamines were cleaved at the carbon-bromine bond or at the benzylic position to afford corresponding hydrogenated products in food yields without the use of compressed hydrogen gas and without requiring any special apparatus.

引用

页码：1405 / 1406

页数：2

共 4 条

[1] Nickel catalyzed deoxygenative cross-coupling of benzyl alcohols with aryl-bromides
Chenniappan, Vinoth Kumar
Peck, Devin
Rahaim, Ronald
TETRAHEDRON LETTERS, 2020, 61 (14)
[2] Nickel-catalyzed C-O bond reduction of aryl and benzyl 2-pyridyl ethers
Li, Jing
Wang, Zhong-Xia
CHEMICAL COMMUNICATIONS, 2018, 54 (17) : 2138 - 2141
[3] Acetyl bromide-alcohols as convenient reaction systems for: a) Removal of N-tert-Boc, N-Cbz and N-Ac protective groups, b) Esterifications and transesterifications, c) Debenzylation of aryl-O-benzyl ethers
Department of Chemistry, Bar Ilan University, Ramat Gan 52900, Israel
Synth. Commun., 8 (1405-1408):
[4] Acetyl bromide-alcohols as convenient reaction systems for:: a) removal of N-tert-Boc, N-CBZ and N-Ac protective groups b) esterifications and transesterification c) debenzylation of aryl-O-benzyl ethers
Lesk, A
Nudelman, A
SYNTHETIC COMMUNICATIONS, 1999, 29 (08) : 1405 - 1408

← 1 →