A Robust and Broadly Applicable Cobalt-Catalyzed Cross-Coupling of Functionalized Bench-Stable Organozinc Pivalates with Unsaturated Halides

被引：32
|
作者：
Hammann, Jeffrey M. [1 ]
Lutter, Ferdinand H. [1 ]
Haas, Diana [1 ]
Knochel, Paul [1 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13,Haus F, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 04期
关键词：
cobalt; cross-coupling; N-heterocycles; zinc; zinc pivalate; LATE-STAGE FUNCTIONALIZATION; C-H FUNCTIONALIZATION; (HETERO)ARYLZINC REAGENTS; ACTIVE CATALYST; ZINC REAGENTS; ARYL; DIVERSIFICATION; ARYLMAGNESIUM; MILD; BORYLATION;
D O I：
10.1002/anie.201610324
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a robust and broadly applicable CoCl2-catalyzed cross-coupling between functionalized aryl and heteroaryl zinc pivalates and various electron-poor aryl and heteroaryl halides (X = Cl, Br, I). Couplings with (E)- or (Z)-bromo- or iodo-alkenes proceed with retention of configuration. Also, alkynyl bromides react with arylzinc pivalates providing arylated alkynes.
引用
收藏
页码：1082 / 1086
页数：5
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