Background. Adhesively luted all-ceramic restorations preserve and stabilize weakened tooth structure, but there is little published information about the clinical performance of large, all-ceramic restorations. Methods. In this pilot study, the authors placed 58 large, single-tooth, all-ceramic restorations in 26 patients using computer-aided design/computer-aided manufacturing, or CAD/CAM, system (CEREC 2, Sirona Dental systems GmbH, Bensheim, Germany). they documented the maximum height of the restoration and remaining cementoenamel junction, or CEJ. In 21 cases, rubber dam isolation was not possible during adhesive luting. they re-evaluated the restorations after three years according to the U.S. Public Health Service criteria. Results. After three years, the authors rated 56 (97 percent) of the 58 restorations as Bravo or better in regard to marginal integrity, secondary caries (four could not be rated), discoloration and anatomical form. One restoration was rated as Charlie because of poor marginal integrity, and one restoration had to be replaced owing to a bulk fracture. The authors rated the adequacy of proximal contact and occlusal relationships as acceptable-to-good for all restorations after three years. Conclusions. At the three-year recall appointment, the authors found that the adhesively luted all-ceramic restorations had successfully repaired large coronal defects, irrespective of the cavity margin location (that is, coronal or apical to the CEJ). Clinical Implications. Tooth-colored, all-ceramic CAD/CAM-generated restorations are an alternative to conventional restorations if large coronal defects need to be treated.