Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination

被引：21
|
作者：
Tai, Lee-Hwa [1 ]
Zhang, Jiqing [1 ,2 ,3 ]
Auer, Rebecca C. [1 ,4 ,5 ]
机构：
[1] Ottawa Hosp, Res Inst, Ctr Innovat Canc Res, Ottawa, ON, Canada
[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada
[3] Shandong Univ, Hosp 2, Dept Neurosurg, Jinan, Shandong, Peoples R China
[4] Univ Ottawa, Dept Surg, Ottawa, ON, Canada
[5] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期
关键词：
cancer metastases; influenza vaccine; immunosuppression; natural killer cells; surgical stress; NATURAL-KILLER-CELLS; IMMUNOSUPPRESSION; DISEASE;
D O I：
10.4161/onci.26618
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in cancer patients.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics
    Market, Marisa
    Tennakoon, Gayashan
    Scaffidi, Marlena
    Cook, David P.
    Angka, Leonard
    Ng, Juliana
    de Souza, Christiano Tanese
    Kennedy, Michael A.
    Vanderhyden, Barbara C.
    Auer, Rebecca C.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [2] Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells
    Tai, Lee-Hwa
    Zhang, Jiqing
    Scott, Karen J.
    de Souza, Christiano Tanese
    Alkayyal, Almohanad A.
    Ananth, Anu Abhirami
    Sahi, Shalini
    Adair, Robert A.
    Mahmoud, Ahmad B.
    Sad, Subash
    Bell, John C.
    Makrigiannis, Andrew P.
    Melcher, Alan A.
    Auer, Rebecca C.
    CLINICAL CANCER RESEARCH, 2013, 19 (18) : 5104 - 5115
  • [3] The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction
    Market, Marisa
    Baxter, Katherine E.
    Angka, Leonard
    Kennedy, Michael A.
    Auer, Rebecca C.
    CANCERS, 2019, 11 (01):
  • [4] Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells
    Tai, Lee-Hwa
    de Souza, Christiano Tanese
    Belanger, Simon
    Ly, Lundi
    Alkayyal, Almohanad A.
    Zhang, Jiqing
    Rintoul, Julia L.
    Ananth, Abhirami A.
    Lam, Tiffany
    Breitbach, Caroline J.
    Falls, Theresa J.
    Kim, David H.
    Bell, John C.
    Makrigiannis, Andrew P.
    Auer, Rebecca A.
    CANCER RESEARCH, 2013, 73 (01) : 97 - 107
  • [5] Surgery-induced Expansion of Myeloid Derived Suppressor Cells Leads to Natural Killer Cell Dysfunction and Postoperative Metastases
    Bennett, S. A.
    Tai, L.
    Alkayyal, A.
    Sahi, S.
    Zhang, J.
    Ananth, A. A.
    de Souza, C. Tanese
    Auer, R. A.
    ANNALS OF SURGICAL ONCOLOGY, 2014, 21 : S15 - S15
  • [6] Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer
    Svatek, Robert S.
    Ji, Niannian
    de Leon, Essel
    Mukherjee, Neelam Z.
    Kabra, Aashish
    Hurez, Vincent
    Nicolas, Marlo
    Michalek, Joel E.
    Javors, Martin
    Wheeler, Karen
    Sharp, Z. Dave
    Livi, Carolina B.
    Shu, Zhen-Ju
    Henkes, David
    Curiel, Tyler J.
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (03) : 466 - 475
  • [7] Breast Cancer Surgery-Induced Immunomodulation
    Boomsma, Martijn F.
    Garssen, Bert
    Slot, Edith
    Berbee, Monique
    Berkhof, Johannes
    Meezenbroek, Eltica De Jager
    Slieker, Walentina
    Visser, Adriaan
    Meijer, Sybren
    Beelen, Robert H. J.
    JOURNAL OF SURGICAL ONCOLOGY, 2010, 102 (06) : 640 - 648
  • [8] Surgery-Induced Immunomodulation in Breast Cancer
    Chen, Xue-Bo
    Fang, Xue-Dong
    Zhang, Hong-Liang
    JOURNAL OF SURGICAL ONCOLOGY, 2011, 103 (02) : 197 - 197
  • [9] Systemic inflammation enhances surgery-induced cognitive dysfunction in mice
    Fidalgo, Antonio Rei
    Cibelli, Mario
    White, John P. M.
    Nagy, Istvan
    Maze, Mervyn
    Ma, Daqing
    NEUROSCIENCE LETTERS, 2011, 498 (01) : 63 - 66
  • [10] Curcumin attenuates surgery-induced cognitive dysfunction in aged mice
    Xiang Wu
    Huixin Chen
    Chunhui Huang
    Xinmei Gu
    Jialing Wang
    Dilin Xu
    Xin Yu
    Chu Shuai
    Liping Chen
    Shun Li
    Yiguo Xu
    Tao Gao
    Mingrui Ye
    Wei Su
    Haixiong Liu
    Jinrong Zhang
    Chuang Wang
    Junping Chen
    Qinwen Wang
    Wei Cui
    Metabolic Brain Disease, 2017, 32 : 789 - 798
12345