[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Div Neurol, Shatin, Hong Kong, Peoples R China
[2] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
[3] Chinese Cochrane Ctr, Hong Kong Branch, Div Epidemiol, Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China
[4] Univ Nottingham, Stroke Trials Unit, Nottingham NG7 2RD, England
[5] Univ London, Stroke & Dementia Res Ctr, London, England
[6] Michigan State Univ, Coll Med, Dept Translat Sci & Mol Med, Grand Rapids, MI USA
[7] St Marys Hlth Care, Grand Rapids, MI USA