Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

被引：0
|
作者：
Mburu, Maureen
Ghosh, Samit
Chen, Xucai
Ofori-Acquah, Solomon Fiifi
机构：
来源：
BLOOD | 2020年 / 136卷
关键词：
D O I：
10.1182/blood-2020-142783
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice
    Ghosh, Samit
    Ihunnah, Chibueze A.
    Hazra, Rimi
    Walker, Aisha L.
    Hansen, Jason M.
    Archer, David R.
    Owusu-Ansah, Amma T.
    Ofori-Acquah, Solomon F.
    JCI INSIGHT, 2016, 1 (04)
  • [2] Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model
    Zhu, Xingguo
    Pace, Betty S.
    BLOOD, 2017, 130
  • [3] Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice
    Ghosh, Samit
    Hansen, Jason
    Hazra, Rimi
    Archer, David R.
    Ofori-Acquah, Solomon F.
    BLOOD, 2014, 124 (21)
  • [4] Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease
    Mburu, Maureen
    Feroze, Rafey
    Whitehurst, Daniel
    Chen, Xucai
    Ghosh, Samit
    Ofori-Acquah, Solomon Fiifi
    Villanueva, Flordeliza S.
    BLOOD, 2017, 130
  • [5] Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice
    Ihunnah, Chibueze A.
    Ghosh, Samit
    Hahn, Scott A.
    Straub, Adam C.
    Ofori-Acquah, Solomon F.
    BLOOD, 2016, 128 (22)
  • [6] Zinc deficiency worsens and zinc supplement prevents the development of diabetic cardiomyopathy, respectively, in the db/db mice: A key role of Nrf2
    Wang, Bowei
    Wang, Shudong
    Tong, Jian
    Wang, Yuehui
    Cai, Lu
    FASEB JOURNAL, 2017, 31
  • [7] Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice
    Ghosh, Samit
    Ihunnah, Chibueze A.
    Hazra, Rimi
    Owusu-Ansah, Amma T.
    Hansen, Jason M.
    Archer, David R.
    Ofori-Acquah, Solomon Fiifi
    BLOOD, 2015, 126 (23)
  • [8] Nrf2 Activation With CDDO-Methyl Promotes Beneficial and Deleterious Clinical Effects in Transgenic Mice With Sickle Cell Anemia
    Ihunnah, Chibueze A.
    Ghosh, Samit
    Hahn, Scott
    Straub, Adam C.
    Ofori-Acquah, Solomon F.
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [9] Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model
    Zhu, Xingguo
    Xi, Caixia
    Thomas, Bobby
    Pace, Betty S.
    BLOOD, 2018, 131 (05) : 558 - 562
  • [10] Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
    Keleku-Lukwete, Nadine
    Suzuki, Mikiko
    Otsuki, Akihito
    Tsuchida, Kouhei
    Katayama, Saori
    Hayashi, Makiko
    Naganuma, Eriko
    Moriguchi, Takashi
    Tanabe, Osamu
    Engel, James Douglas
    Imaizumi, Masue
    Yamamoto, Masayuki
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (39) : 12169 - 12174
12345