Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

被引：5
|
作者：
Elias, Peter M. [1 ]
Schmuth, Matthias [1 ]
机构：
[1] VA Med Ctr, Dermatol Serv 190, San Francisco, CA 94121 USA
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2009年 / 9卷 / 04期
关键词：
OF-FUNCTION MUTATIONS; HUMAN STRATUM-CORNEUM; EPIDERMAL PERMEABILITY; HISTIDINE-RICH; FILAGGRIN; GENE; NETHERTON; PROTEINS; POLYMORPHISMS; KERATINOCYTES;
D O I：
10.1007/s11882-009-0037-y
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.
引用
收藏
页码：265 / 272
页数：8
相关论文
共 50 条
  • [1] Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M. Elias
    Matthias Schmuth
    Current Allergy and Asthma Reports, 2009, 9 : 265 - 272
  • [2] Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Elias, Peter M.
    Schmuth, Matthias
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 9 (05) : 437 - 446
  • [3] Is the skin barrier abnormal in dogs with atopic dermatitis?
    Olivry, Thierry
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2011, 144 (1-2) : 11 - 16
  • [4] Skin barrier in atopic dermatitis
    Sant'Anna Addor, Flavia Alvim
    Aoki, Valeria
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2010, 85 (02) : 184 - 194
  • [5] Skin Barrier in Atopic Dermatitis
    Schmuth, Matthias
    Eckmann, Sonja
    Moosbrugger-Martinz, Verena
    Ortner-Tobider, Daniela
    Blunder, Stefan
    Trafoier, Thomas
    Gruber, Robert
    Elias, Peter M.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (05)
  • [6] Skin barrier in atopic dermatitis
    Kezic, Sanja
    Novak, Natalija
    Jakasa, Ivone
    Jungersted, Jakob M.
    Simon, Michel
    Brandner, Johanna M.
    Middelkamp-Hup, Maritza A.
    Weidinger, Stephan
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2014, 19 : 541 - 556
  • [7] The etiopathogenesis of atopic dermatitis: Barrier disruption, immunological derangement, and pruritus
    Rerknimitr P.
    Otsuka A.
    Nakashima C.
    Kabashima K.
    Inflammation and Regeneration, 37 (1)
  • [8] Atopic dermatitis: A skin barrier disease
    Egelrud, Torbjoern
    ACTA DERMATO-VENEREOLOGICA, 2007, 87 (06) : 483 - 484
  • [9] Atopic dermatitis: the skin barrier and beyond
    Tsakok, T.
    Woolf, R.
    Smith, C. H.
    Weidinger, S.
    Flohr, C.
    BRITISH JOURNAL OF DERMATOLOGY, 2019, 180 (03) : 464 - 474
  • [10] Effect of Skin Barrier on Atopic Dermatitis
    Liu, Hanye
    DERMATITIS, 2025, 36 (01) : 37 - 45
12345