Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Selective carbon-hydrogen activation reactions can be accomplished in a predictive manner using directing auxiliaries. However, the majority of directing groups discovered to date are difficult to remove or to transform into a desirable functionality. Recently, removable, cleavable, and redox-neutral directing groups have been developed that significantly broaden both the substrate scope and synthetic diversity of carbon-hydrogen functionalization reactions. In this short account, we summarize recent progress we have made in the development of multitasking (removable, cleavable, redox-neutral, manipulable) directing groups for carbon-hydrogen activation reactions. 1 Introduction 2 Triazene 3 Nitrous Amide 4 Pyrazolidinone 5 N-Oxyacetamide 6 Conclusion