Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials

被引：68

作者：

Shi, Wen ^{[1
]}

Harris, Adrian L. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK,Mol Oncol Labs, Oxford OX3 9DS, England

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2006年 / 11卷 / 01期

关键词：

Notch signaling; breast cancer; angiogenesis; gamma-secretase inhibitors; anti-Notch therapy;

D O I：

10.1007/s10911-006-9011-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch signaling is an evolutionarily conserved pathway that regulates numerous physiological processes. Disruption of Notch has been implicated in multiple tumor types. Evidence from in vitro experiments, mouse models and human tumor samples indicates that Notch plays a predominantly oncogenic role in breast cancer and interacts with other pathways involved in tumorigenesis. In addition, Notch signaling is required for physiological angiogenesis and may promote tumor angiogenesis. A variety of strategies for blocking Notch signaling, in particular gamma-secretase inhibition, are discussed as potential therapies for breast cancer and tumor angiogenesis.

引用

页码：41 / 52

页数：12

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