The stationary distribution and extinction of a double thresholds HTLV-I infection model with nonlinear CTL immune response disturbed by white noise

被引:5
|
作者
Qi, Kai [1 ]
Jiang, Daqing [2 ,3 ]
Hayat, Tasawar [3 ,4 ]
Alsaedi, Ahmed [4 ]
机构
[1] China Univ Petr East China, Coll Sci, Qingdao 266580, Shandong, Peoples R China
[2] China Univ Petr East China, Minist Educ, Key Lab Unconvent Oil & Gas Dev, Qingdao 266580, Shandong, Peoples R China
[3] King Abdulaziz Univ, Nonlinear Anal & Appl Math NAAM Res Grp, Jeddah, Saudi Arabia
[4] Quaid I Azam Univ 45320, Dept Math, Islamabad 44000, Pakistan
关键词
HTLV-I infection; CTL immune response; CD4+T cells; stationary distribution; extinction; MATHEMATICAL-MODEL; DYNAMICS;
D O I
10.1142/S179352451950058X
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper investigates the stochastic HTLV-I infection model with CTL immune response, and the corresponding deterministic model has two basic reproduction numbers. We consider the nonlinear CTL immune response for the interaction between the virus and the CTL immune cells. Firstly, for the theoretical needs of system dynamical behavior, we prove that the stochastic model solution is positive and global. In addition, we obtain the existence of ergodic stationary distribution by stochastic Lyapunov functions. Meanwhile, sufficient condition for the extinction of the stochastic system is acquired. Reasonably, the dynamical behavior of deterministic model is included in our result of stochastic model when the white noise disappears.
引用
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页数:20
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