Estrogen receptor-alpha (ER-α) suppresses expression of its variant ER-α36

被引:81
|
作者
Zou, Yi [1 ]
Ding, Ling [1 ]
Coleman, Megan [1 ]
Wang, Zhaoyi [1 ]
机构
[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA
来源
FEBS LETTERS | 2009年 / 583卷 / 08期
关键词
Promoter; Estrogen receptor; ER-alpha; 36; Breast cancer; HUMAN BREAST CARCINOMAS; ELEMENT HALF-SITE; BINDING-SITES; IDENTIFICATION; GROWTH; GENE; ACTIVATION; PATHWAYS; CANCER; WT1;
D O I
10.1016/j.febslet.2009.03.047
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recently, we identified and cloned a membrane-based estrogen receptor (ER), ER-alpha 36, which is transcribed from a previously unidentified promoter in the first intron of the original ER-alpha gene. We cloned the 5' flanking region of ER-alpha 36 and found the cloned DNA sequence possessed strong promoter activity. A single transcription initiation site was mapped and a number of putative regulatory elements for various transcription factors such as the Wilms' tumor suppressor, WT1 and estrogen receptor (ER) were identified in this region. Transient co-transfection experiments further demonstrated that ER-alpha suppresses ER-alpha 36 promoter activity in an estrogen-independent manner, which can be released by ER-alpha 36 itself. (C) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码:1368 / 1374
页数:7
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