Total Synthesis of Ellipticine Quinones, Olivacine, and Calothrixin B

被引：57
|
作者：
Ramkumar, Nagarajan [1 ]
Nagarajan, Rajagopal [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 02期
关键词：
FRIEDEL-CRAFTS HYDROXYALKYLATION; INDOLE-2,3-DICARBOXYLIC ANHYDRIDE; EFFICIENT SYNTHESIS; DIRECTED ORTHO; PHASE-II; METALATION; DERIVATIVES; CANCER; ALKALOIDS; PYRIDINES;
D O I：
10.1021/jo402593w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct route to the synthesis of biologically active ellipticine quinones, olivacine, and calothrbcin B is described. The prominent key steps involved are Friedel-Crafts hydroxyalkylation followed by oxidation and directed ortho-lithiation reactions of readily available indole-2-carboxylate esters with appropriately substituted pyridine and quinoline carboxaldehydes.
引用
收藏
页码：736 / 741
页数：6
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