Monitoring levels of preservative sensitivity in Europe -: A 10-year overview (1991-2000)

被引：164

作者：

Wilkinson, JD

Shaw, S

Andersen, KE

Brandao, FM

Bruynzeel, DP

Bruze, M

Camarasa, JMG

Diepgen, TL

Ducombs, G

Frosch, PJ

Goossens, A

Lachappelle, JM

Lahti, A

Menné, T

Seidenari, S

Tosti, A

Wahlberg, JE

机构：

[1] Amersham Hosp, Dept Dermatol, Amersham HP7 0JD, Bucks, England

[2] Odense Univ Hosp, Dept Dermatol, Odense, Denmark

[3] Hosp Garcia de Orta, Dept Dermatol, Almada, Portugal

[4] Free Univ Amsterdam Hosp, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands

[5] Univ Witten Herdecke, Dept Dermatol, Dortmund, Germany

[6] Univ Oulu, Dept Dermatol, SF-90220 Oulu, Finland

[7] Gentofte Univ Hosp, Dept Dermatol, Copenhagen, Denmark

[8] Univ Modena, Dept Dermatol, I-41100 Modena, Italy

[9] Univ Bologna, Dept Dermatol, I-40126 Bologna, Italy

[10] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, Malmo, Sweden

[11] Univ Hosp, Dept Occupat & Environm Dermatol, Heidelberg, Germany

[12] Noubacka, Dept Occupat & Environm Dermatol, Stockholm, Sweden

[13] Hosp March, Serv Dermatol, Barcelona, Spain

[14] Hop St Andre, Serv Dermatol, Bordeaux, France

[15] UZKU Leuven, Dept Dermatol Contact Allergy, Louvain, Belgium

[16] Univ Louvain, Unit Occupat & Environm Dermatol, Brussels, Belgium

来源：

CONTACT DERMATITIS | 2002年 / 46卷 / 04期

关键词：

5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one; diazolidinyl urea; formaldehyde; imidazolidinyl urea; methyldibromoglutaronitrile; parabens; patch test sensitization; preservatives; quaternium-15;

D O I：

10.1034/j.1600-0536.2002.460404.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.

引用

页码：207 / 210

页数：4

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