Simultaneous estimation of nebivolol hydrochloride and valsartan using RP HPLC

被引：0
|
作者：
Kokil, S. U. [1 ]
Bhatia, M. S. [1 ]
机构：
[1] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut Chem, Kolhapur 416013, Maharashtra, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 71卷 / 02期
关键词：
Nebivolol hydrochloride; valsartan; fenofibrate; ion-pair; RP-HPLC; HUMAN PLASMA; ATENOLOL; QUANTIFICATION; BLOCKERS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, a rapid, precise, accurate, specific and sensitive ion-paired reverse phase liquid chromatographic method has been developed for the simultaneous estimation of nebivolol hydrochloride and valsartan in their capsule formulation. The chromatographic method was standardized using a HIQ sil C18 column (250x4.6 mm i.d., 5 m particle size) with UV detection at 289 nm and flow rate of 1 ml/min. The mobile phase consisting of methanol:water (80:20 v/v) with addition of 0.1 percent 1-hexanesulfonic acid monohydrate sodium salt as an ion-pairing reagent was selected. The method was validated and produced accurate and precise results for estimation of the two drugs.
引用
收藏
页码：111 / 114
页数：4
相关论文
共 50 条
  • [1] Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan and Nebivolol Hydrochloride and Hydrochlorothiazide in Pharmaceutical Formulations by UV Spectrophotometric Methods
    Meyyanathan, S. N.
    Birajdar, Arunadevi S.
    Suresh, Bhojraj
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2010, 44 (02) : 156 - 159
  • [2] A New RP-HPLC Method for Simultaneous Estimation of Nebivolol Hydrochloride and Hydrochlorthiazide in Dosage Forms
    Gupta, Y.
    Shrivastava, A.
    Duggal, D.
    Patel, A.
    Agrawal, S.
    [J]. JOURNAL OF YOUNG PHARMACISTS, 2009, 1 (03) : 264 - 269
  • [3] Simple Simultaneous Estimation of Nebivolol HCl and Valsartan in Solid Dosage Form by RP-HPLC Method
    Birajdar, Arunadevi S.
    Meyanathan, S. N.
    Suresh, B.
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (02) : 192 - 192
  • [4] RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN BULK AND DOSAGE FORM
    Jadhav, P. B.
    Parwe, C. D.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2019, 10 (02): : 756 - 762
  • [5] A NEW RP-HPLC METHOD FOR THE SIMULATANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN TABLETS
    Krishna, Bhuvanagiri
    Babu, Gudimitla Raveendra
    Ramayyappa, Muddala
    Kumar, Averineni Ravi
    [J]. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (04): : 2964 - 2969
  • [6] Stability Indicating RP-HPLC Estimation of Nebivolol Hydrochloride in Pharmaceutical Formulations
    Shah, D. A.
    Bhatt, K. K.
    Mehta, R. S.
    Baldania, S. L.
    Gandhi, T. R.
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 70 (05) : 591 - 595
  • [7] Simultaneous Estimation of Cilnidipine and Valsartan by RP-HPLC in Tablet Formulation
    Kachave, Ramanlal N.
    Kale, Mayura
    Wagh, Rajendra D.
    [J]. EURASIAN JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 11 (05): : 245 - 253
  • [8] A Validated RP-HPLC Method for Simultaneous Estimation of Nebivolol and Hydrochlorothiazide in Tablets
    Meyyanathan, S. N.
    Rajan, S.
    Muralidharan, S.
    Birajdar, Arunadevi S.
    Suresh, B.
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 70 (05) : 687 - 689
  • [9] SIMULTANEOUS DETERMINATION OF NEBIVOLOL HCL AND VALSARTAN IN SOLID DOSAGE FORM BY SPECTROPHOTOMETRIC AND RP-HPLC METHOD
    Birajdar, Arunadevi S.
    Meyyanathan, Subramania Nainar
    Suresh, Bhojraj
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (02): : 424 - 431
  • [10] Simultaneous Estimation of Rofecoxib and Tizanidine Hydrochloride in Tablets by RP-HPLC
    Rao, A. Lakshmana
    Varma, D. Praveen
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (01) : 95 - 99
12345