Hedgehog Signaling Regulates the Survival of Gastric Cancer Cells by Regulating the Expression of Bcl-2

被引：37

作者：

Han, Myoung-Eun ^{[1
,2
]}

Lee, Young-Suk ^{[1
]}

Baek, Sun-Yong ^{[1
]}

Kim, Bong-Seon ^{[1
]}

Kim, Jae-Bong ^{[1
]}

Oh, Sae-Ock ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan 626770, South Korea

[2] Pusan Natl Univ, Med Res Ctr Ischem Tissue Regenerat, Yangsan 626770, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 07期

关键词：

gastric cancer; hedgehog signaling; apoptosis; Bcl-2; SONIC HEDGEHOG; DEATH; PATHWAY; FAMILY; GROWTH; SKIN; DIFFERENTIATION; MEDULLOBLASTOMA; CARCINOGENESIS; CYCLOPAMINE;

D O I：

10.3390/ijms10073033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is the second most common cause of cancer deaths worldwide. The underlying molecular mechanisms of its carcinogenesis are relatively poorly characterized. Hedgehog (Hh) signaling, which is critical for development of various organs including the gastrointestinal tract, has been associated with gastric cancer. The present study was undertaken to reveal the underlying mechanism by which Hh signaling controls gastric cancer cell proliferation. Treatment of gastric cancer cells with cyclopamine, a specific inhibitor of Hh signaling pathway, reduced proliferation and induced apoptosis of gastric cancer cells. Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9. Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment. These results suggest that Hh signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.

引用

页码：3033 / 3043

页数：11

共 50 条

[1] The Expression of Bcl-2 and BID in Gastric Cancer Cells
Gryko, Mariusz
Pryczynicz, Anna
Zareba, Konrad
Kedra, Boguslaw
Kemona, Andrzej
Guzinska-Ustymowicz, Katarzyna
JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014
[2] MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells
Boucher, MJ
Morisset, J
Vachon, PH
Reed, JC
Lainé, J
Rivard, N
JOURNAL OF CELLULAR BIOCHEMISTRY, 2000, 79 (03) : 355 - 369
[3] Bcl-2 expression as a prognostic factor of survival of gastric carcinoma
Inada, T
Kikuyama, S
Ichikawa, A
Igarashi, S
Ogata, Y
ANTICANCER RESEARCH, 1998, 18 (3B) : 2003 - 2010
[4] Prognostic value of bcl-2 expression in gastric cancer
Müller, W
Schneiders, A
Hommel, G
Gabbert, HE
ANTICANCER RESEARCH, 1998, 18 (6B) : 4699 - 4704
[5] HEDGEHOG SIGNALING REGULATES PDL-1 EXPRESSION IN GASTRIC CANCER CELLS TO INDUCE TUMOR PROLIFERATION
Chakrabarti, Jayati
Holokai, Loryn L.
Bertaux-Skeirik, Nina
Syu, LiJyun
Broda, Taylor
Chang, Julie
Teal, Emma L.
Wells, James
Dlugosz, Andrzej A.
Zavros, Yana
GASTROENTEROLOGY, 2017, 152 (05) : S1311 - S1312
[6] Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis
Haidong Cheng
Xiumei Wang
Tao Li
Lin Chen
Medical Oncology, 2015, 32
[7] ANDROGEN REGULATES THE EXPRESSION OF CRITICAL HEDGEHOG SIGNALING COMPONENTS IN PROSTATE CANCER CELLS
Chen, Mengqian
Tanner, Matthew
Levine, Alice C.
Levina, Elina
Buttyan, Ralph
JOURNAL OF UROLOGY, 2009, 181 (04): : 96 - 96
[8] Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis
Cheng, Haidong
Wang, Xiumei
Li, Tao
Chen, Lin
MEDICAL ONCOLOGY, 2015, 32 (01)
[9] Bcl-2 expression, cell differentiation and survival in primary breast cancer
Vandebroek, A
Makar, A
Joosens, E
Van Leuven, H
Declercq, S
Beelaers, W
Van den Weyngaert, D
Gerris, J
Becquart, D
Kockx, M
EUROPEAN JOURNAL OF CANCER, 1999, 35 : S88 - S88
[10] EBP50 regulates the apoptosis of pancreatic cancer cells by decreasing the expression levels of Bcl-2
Ji, Mengyao
Yuan, Lei
Lv, Xiaoguang
Dong, Weiguo
Peng, Xiulan
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2014, 8 (03) : 919 - 924

← 1 2 3 4 5 →