A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice

被引：36
|
作者：
Mai, Hengtang [1 ]
Wang, Yu [2 ]
Li, Shuang [1 ]
Jia, Ruizhen [1 ]
Li, Sixian [1 ]
Peng, Qian [1 ]
Xie, Yan [1 ]
Hu, Xiang [2 ]
Wu, Song [1 ]
机构：
[1] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430072, Hubei, Peoples R China
[2] Wuhan Univ, Dept Orthopaed Trauma & Microsur, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 51期
基金：
中国国家自然科学基金;
关键词：
INTRACELLULAR PH; SKIN SURFACE;
D O I：
10.1039/c9cc02289a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A pH-sensitive near-infrared fluorescent probe with alkaline pK(a), AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.
引用
收藏
页码：7374 / 7377
页数：4
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