Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman

被引：18
|
作者：
Fliesser, E. E. [1 ]
Korsten, P. [1 ]
Koziolek, M. J. [1 ]
Niewold, T. B. [2 ,3 ]
Patschan, D. [1 ]
Mueller, G. A. [1 ]
Patschan, S. A. [1 ]
机构：
[1] Univ Med Gottingen, Dept Nephrol & Rheumatol, Gottingen, Germany
[2] Mayo Clin, Div Rheumatol, Rochester, MN USA
[3] Mayo Clin, Dept Immunol, Rochester, MN USA
来源：
LUPUS | 2013年 / 22卷 / 14期
关键词：
Proliferative lupus nephritis; belimumab; systemic lupus erythematosus; mycophenolate mofetil; DISEASE-ACTIVITY; ERYTHEMATOSUS; CLASSIFICATION;
D O I：
10.1177/0961203313504145
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report the case of a 19-year-old woman with progressive proliferative lupus nephritis (LN) class III after induction and maintenance therapy with mycophenolate mofetil (MMF). Despite a satisfying clinical improvement proteinuria progressed under this medication. We treated the patient with additional belimumab after discussing other options. Following treatment with belimumab, proteinuria rapidly improved to almost normal levels and clinical remission lasted. Belimumab might hold promise for this indication.
引用
收藏
页码：1523 / 1525
页数：3
相关论文
共 41 条
  • [1] Mycophenolate mofetil for treatment of refractory lupus nephritis
    Johnson, DW
    [J]. INTERNAL MEDICINE JOURNAL, 2001, 31 (05) : 312 - 312
  • [2] MYCOPHENOLATE MOFETIL IN THE TREATMENT OF REFRACTORY LUPUS NEPHRITIS
    Tan, C. H.
    Vathsala, A.
    Chiang, G. S. C.
    Howe, H. S.
    [J]. NEPHROLOGY, 2005, 10 : A171 - A171
  • [3] Defining the Role of Mycophenolate Mofetil in the Treatment of Proliferative Lupus Nephritis
    Oliver Dr Lenz
    Alessia Fornoni
    Gabriel Contreras
    [J]. Drugs, 2005, 65 : 2429 - 2436
  • [4] Defining the role of mycophenolate mofetil in the treatment of proliferative lupus nephritis
    Lenz, O
    Fornoni, A
    Contreras, G
    [J]. DRUGS, 2005, 65 (17) : 2429 - 2436
  • [5] Successful treatment of severe refractory lupus hepatitis with mycophenolate mofetil
    Tagawa, Y.
    Saito, T.
    Takada, K.
    Kawahata, K.
    Kohsaka, H.
    [J]. LUPUS, 2016, 25 (05) : 543 - 546
  • [6] Successful Treatment with Mycophenolate Mofetil and Tacrolimus in Juvenile Severe Lupus Nephritis
    Kise, Tomoo
    Yoshimura, Hiroshi
    Fukuyama, Shigeru
    Uehara, Masatsugu
    [J]. CASE REPORTS IN PEDIATRICS, 2015, 2015
  • [7] Mycophenolate mofetil for treatment of refractory lupus nephritis: four pilot cases
    Wallman, L
    Stewart, G
    Chapman, J
    O'Connell, P
    Fulcher, D
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 2000, 30 (06): : 712 - 715
  • [8] COMBINATION THERAPY OF MYCOPHENOLATE MOFETIL AND CYCLOSPORINE A FOR INDUCTION TREATMENT OF REFRACTORY LUPUS NEPHRITIS: SUCCESSFUL TREATMENT OF DIFFICULT CASES
    Jesus, D.
    Rodrigues, M.
    Da Silva, J. A. P.
    Ines, L.
    [J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2016, 34 (04) : S81 - S81
  • [9] Multitarget therapy of mycophenolate mofetil and cyclosporine A for induction treatment of refractory lupus nephritis
    Jesus, D.
    Rodrigues, M.
    da Silva, J. A. P.
    Ines, L.
    [J]. LUPUS, 2018, 27 (08) : 1358 - 1362
  • [10] Effect of maintenance treatment with mycophenolate mofetil on chronic inflammatory status in proliferative lupus nephritis
    Balletta, Mario
    Esposito, Pasquale
    Del Prete, Marco
    De Cicco, Marco
    Marotta, Paola
    Andrietti, Marco
    Procino, Alfredo
    Bisesti, Vincenzo
    Postiglione, Loredana
    Cianciaruso, Bruno
    Russo, Domenico
    Memoli, Bruno
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 : 93 - 94
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