Antitumor metastasis pregnane alkaloids from Pachysandra terminalis

被引：17

作者：

Zhao, Chuan ^{[1
]}

Gan, Chun-Chun ^{[2
]}

Jin, Mei-Na ^{[2
]}

Tang, Sheng-An ^{[2
]}

Qin, Nan ^{[1
]}

Duan, Hong-Quan ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 05期

基金：

中国国家自然科学基金;

关键词：

pregnane alkaloids; antitumor metastasis; Pachysandra terminalis; PKC zeta; KINASE-C-ZETA; CHEMOTAXIS; GROWTH;

D O I：

10.1080/10286020.2014.893511

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new pregnane alkaloids, named terminamines H-J (1-3), together with two known alkaloids (4 and 5), were isolated from the ethanol extract of Pachysandra terminalis. The structures of isolated compounds were elucidated by spectroscopic methods, including H-1 and C-13 NMR, 2D NMR, and HR-ESI-MS. Compounds 1, 4, and 5 revealed significant anti-metastasis activities. In addition, compound 1 inhibited the expression of p-PKC zeta in MDA-MB-231 cells, and compound 4 inhibited the expressions of p-PKC zeta in MDA-MB-231 and A549 cells.

引用

页码：440 / 446

页数：7

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