Distinct brain structure and behavior related to ADHD and conduct disorder traits

被引：33

作者：

Bayard, Frida ^{[1
]}

Thunell, Charlotte Nymberg ^{[1
]}

Abe, Christoph ^{[1
]}

Almeida, Rita ^{[2
]}

Banaschewski, Tobias ^{[3
]}

Barker, Gareth ^{[4
]}

Bokde, Arun L. W. ^{[5
,6
]}

Bromberg, Uli ^{[7
]}

Buechel, Christian ^{[7
]}

Quinlan, Erin Burke ^{[8
,9
]}

Desrivieres, Sylvane ^{[8
,9
]}

Flor, Herta ^{[10
,11
]}

Frouin, Vincent ^{[12
]}

Garavan, Hugh ^{[13
,14
]}

Gowland, Penny ^{[15
]}

Heinz, Andreas ^{[16
]}

Ittermann, Bernd ^{[17
]}

Martinot, Jean-Luc ^{[18
,19
,20
]}

Martinot, Marie-Laure Paillere ^{[18
,21
]}

Nees, Frauke ^{[3
,10
]}

Orfanos, Dimitri Papadopoulos ^{[12
]}

Paus, Tomas ^{[22
,23
,24
]}

Poustka, Luise ^{[25
,26
]}

Conrod, Patricia ^{[27
]}

Stringaris, Argyris ^{[28
]}

Struve, Maren ^{[3
]}

Penttila, Jani ^{[29
]}

Kappel, Viola ^{[30
]}

Grimmer, Yvonne ^{[3
]}

Fadai, Tahmine ^{[7
]}

van Noort, Betteke ^{[30
]}

Smolka, Michael N. ^{[31
,32
]}

Vetter, Nora C. ^{[31
,32
]}

Walter, Henrik ^{[16
]}

Whelan, Robert ^{[33
,34
]}

Schumann, Gunter ^{[8
,9
]}

Petrovic, Predrag ^{[1
]}

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, Stockholm, Sweden

[3] Heidelberg Univ, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Med Fac Mannheim, Mannheim, Germany

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Neuroimaging Sci, London, England

[5] Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland

[6] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland

[7] Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-20246 Hamburg, Germany

[8] Kings Coll London, Ctr Populat Neurosci & Stratified Med PONS, London, England

[9] Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England

[10] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[11] Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany

[12] Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France

[13] Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA

[14] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

[15] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England

[16] Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, Campus Charite Mitte,Charitepl 1, Berlin, Germany

[17] Phys Techn Bundesanstalt PTB, Berlin, Germany

[18] Univ Paris 05, Univ Paris Sud Paris Saclay, INSERM, Unit 1000 Neuroimaging & Psychiat, Orsay, France

[19] Serv Hosp Freder Joliot, Orsay, France

[20] Maison Solenn, Paris, France

[21] Cochin Hosp, AP HP, Dept Adolescent Psychopathol & Med, Maison Solenn, Paris, France

[22] Univ Toronto, Rotman Res Inst, Baycrest, Toronto, ON M6A 2E1, Canada

[23] Univ Toronto, Dept Psychol, Toronto, ON M6A 2E1, Canada

[24] Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada

[25] Med Univ Vienna, Clin Child & Adolescent Psychiat, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[26] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany

[27] Univ Montreal, CHU Ste Justine Hosp, Dept Psychiat, Montreal, PQ, Canada

[28] NIMH, NIH, Bethesda, MD 20892 USA

[29] Psychosocial Serv Adolescent Outpatient Clin Kaup, Dept Social & Hlth Care, Lahti, Finland

[30] Charite Univ Med Berlin, Dept Child & Adolescent Psychiat Psychosomat & Ps, Campus Charite Mitte,Charitepl 1, Berlin, Germany

[31] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[32] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

[33] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland

[34] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

来源：

MOLECULAR PSYCHIATRY | 2020年 / 25卷 / 11期

基金：

英国医学研究理事会;

关键词：

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY DISORDER; GRAY-MATTER VOLUME; BORDERLINE PERSONALITY-DISORDER; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; WORKING-MEMORY; STIMULANT-MEDICATION; CORTICAL DEVELOPMENT; EXECUTIVE FUNCTION;

D O I：

10.1038/s41380-018-0202-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Attention-Deficit/Hyperactivity Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a large comorbidity and shared genetics. At the same time, they entail two different types of symptomology involving mainly non-emotional or emotional dysregulation. Few studies have tried to separate the specific biology underlying these two dimensions. It has also been suggested that both types of conditions consist of extreme cases in the general population where the symptoms are widely distributed. Here we test whether brain structure is specifically associated to ADHD or CD symptoms in a general population of adolescents (n=1093) being part of the IMAGEN project. Both ADHD symptoms and CD symptoms were related to similar and overlapping MRI findings of a smaller structure in prefrontal and anterior cingulate cortex. However, our regions of interest (ROI) approach indicated that gray matter volume (GMV) and surface area (SA) in dorsolateral/dorsomedial prefrontal cortex and caudal anterior cingulate cortex were negatively associated to ADHD symptoms when controlling for CD symptoms while rostral anterior cingulate cortex GMV was negatively associated to CD symptoms when controlling for ADHD symptoms. The structural findings were mirrored in performance of neuropsychological tests dependent on prefrontal and anterior cingulate regions, showing that while performance on the Stop Signal test was specifically related to the ADHD trait, delayed discounting and working memory were related to both ADHD and CD traits. These results point towards a partially domain specific and dimensional capacity in different top-down regulatory systems associated with ADHD and CD symptoms.

引用

页码：3020 / 3033

页数：14

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