Effects of aspirin and nifedipine alone or in combination on hemodynamics in anesthetized dogs

AIM: To study the effects of the combination of aspirin (Asp) and nifedipine (Nif) on hemodynamics in 8 anesthetized dogs. METHODS: Tension time index (TTI), left ventricular work index (LVWI), mean arterial pressure (MAP), and total peripheral vascular resistance (TPVR), femoral artery blood flow (FBF), ventricular systolic pressure (LVSP), maximum of its first derivative (dp/dt(max)), left ventricular end diastolic pressure (LVEBP) and heart rate (HR) were recorded on polygraph and electromagnetic flowmeter. RESULTS: Asp 5, 10 mg . kg(-1), iv exerted a significant effect on the hemodynamic indices, wheras Nif 15 mu g . kg(-1), iv decreased TTI, LVWI, MAP, and TRVR, increased FBF distinctively, and slightly affected LVSP, dp/dt(max), LVEDP, and HR. The effects of Asp in combination with Nif on hemodynamics were similar to those of Nif alone, CONCLUSION: The improvement of cardiovascular function caused by Nif was not affected by the presence of Asp.