Mammalian phosphoinositide-specific phospholipase C

被引：88
|
作者：
Williams, RL [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1441卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
phospholipase C; phosphoinositide; C2; domain; PH domain; signal transduction;
D O I：
10.1016/S1388-1981(99)00150-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian phosphoinositide-specific phospholipases C (PI-PLCs) are involved in most receptor-mediated signal transduction pathways. The mammalian isozymes employ a modular arrangement of domains to achieve a regulated production of two key second messengers. The roles of the PH, EF hand, C2, SH2 and SH3 modules in regulation of these enzymes and in interactions with membranes and other proteins is becoming apparent from recent structural and functional studies. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：255 / 267
页数：13
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