Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

被引：3
|
作者：
Fine, Michael [1 ]
Li, Xiaochun [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA
来源：
NEURON | 2021年 / 109卷 / 02期
关键词：
D O I：
10.1016/j.neuron.2020.12.017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.
引用
收藏
页码：194 / 196
页数：4
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